What is it the cause of polycystic kidney disease

Speaking of polycystic kidney disease polycystic kidney disease etiology explain. Many of my friends are a lot of you want to find out, because in today, with the continuous growth of kidney disease patients, patients with polycystic kidney disease is constantly grew, and for this to the patient's health caused great injuries disease, small or positive recommendation to understand the disease, cystic kidney disease because so many difficult explain what is it?
Everyone knows polycystic kidney disease is a hereditary kidney disease, for many patients who are inherited, sub infantile and adult type, which is relatively rare infantile, adult polycystic kidney disease is an autosomal significantly Genetic, polycystic kidney disease is a common, the incidence rate of about 1/1250, accounting for 10% of ESRD. Polycystic kidney cysts patient with age gradually increases, if not controlled in time, renal cysts continues to increase, there will be oppression around the renal unit will cause the damage, to start the process of renal fibrosis , an early manifestation of urine tests appear: protein and blood cells; if the process of renal fibrosis has not been effectively curb, elevated serum creatinine occurs, eventually develop into end-stage renal failure.
Of course, the cause of polycystic kidney disease in patients with genetic factors in addition to the above, many of the acquired risk factors is indispensable, such as toxins stimulus, a variety of infections, toxins in the human body can cause a variety of cellular tissue and organ damage, not only a threat to the safety of human life, but also lead to human gene mutation, cell mutation, these are likely to induce the appearance of polycystic kidney disease; infection can also cause abnormal body environment, which lead to a favorable change in gene cyst generating environment, to promote internal factors enhance the activity of cysts, eventually leading to the occurrence of polycystic kidney disease. 90% adpkd patients with abnormal gene located on the short arm of chromosome 16, called adpkd1 gene, the gene product is unclear. Many coding genes in the region have been elucidated by cloning, is expected in the near future, adpkd1 can be confirmed. Another 10% less than the abnormal gene in patients with short arm of chromosome 4 is located, called adpkd2 gene, which encodes a product is also unclear. The two groups in the onset of hypertension appear and enter the age of renal failure vary.
Specific factor in the pathogenesis of this disease is actually uncertain course, and today's medical standards are related. Although most symptoms after only adult, but formed in the fetal period begins. Cyst originated in the renal tubules, its liquid properties vary with the site of origin, originated in the proximal tubule, the cyst fluid ingredients such as na +, k +, ci-, h +, creatinine, urea and plasma is similar; it originated in the distal within the cyst fluid na +, k + concentration is low, higher ci-, h +, creatinine and urea concentrations.
For the majority of patients suffering from polycystic kidney disease, their glomerular capsule epithelial cells different from normal growth is also one of significant features, in a mature state of incomplete or re-development, is highly suggestive of bacterial The mature regulatory obstacles, the cells in an immature state, which shows a strong proliferative. On this abnormal cell transport is another significant feature adpkd, the performance is closely related to cellular transport na + -k + -atpase subunit composition, distribution alter the expression and activity; cell signaling abnormalities and changes in ion transport channels. Extracellular matrix dysplasia is adpkd third significant feature.
Above is about polycystic kidney disease etiology tells you about the small series, and if you have on other aspects of the disease of doubt, it is recommended that you have a lot of small series and specialist doctors attending and actively communicate with. After all, for the majority of patients with a friend, if the treatment is not timely, it will give patients life-threatening, please pay attention to starting therapy to Oh!


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