What are the clinical symptoms of polycystic kidney disease

What are the clinical symptoms of polycystic kidney disease? There are a lot of people do not understand what the clinical symptoms of polycystic kidney disease? Clinically most may have a family history of polycystic kidney disease, more men than women, behave differently. Usually no clinical symptoms of polycystic kidney disease, the onset of symptoms after age 30, but also to the 80 to 90-year-old was discovered by chance due. Polycystic kidney disease symptoms following two aspects:

(1) the symptoms of polycystic kidney disease:

Kidney enlargement

Waist, abdominal discomfort, pain or dull, it is due to the increase of renal cysts and renal capsular tension increases or towing vessels and nerves caused by renal pedicle. After intracapsular bleeding or blood clots blocking the ureter cyst infection may exacerbate or sudden pain renal colic.

Hematuria: blood vessel wall caused by rupture will involve candidates gross hematuria.

Proteinuria and white blood cells in urine: urine protein content is generally less than 1 g / 24 hours, more common white blood cells in urine, does not necessarily mean the infection.

Hypertension: common and directly affect the prognosis. Cyst oppression in normal kidney tissue so that local renal ischemia and (or) renal sodium and water retention related.

Renal impairment: Renal dysfunction occurs gradually after the age of 40, to 59 years of age have lost about half of patients with renal function. In addition to cystic renal impairment and oppression, replace the surrounding normal kidney tissue, but still with non-ischemic tissue cysts, high perfusion sclerosis and (or) inflammation, fibrosis, and remnants of normal kidney tissue, high filtration, promote kidney growth factor promote further damage related to the renal unit.

(2) Other symptoms:

Polycystic liver: ADPKD patients 60 years of age 70% can be found in polycystic liver disease, the severity and incidence of renal cysts are not parallel. Approximately 10% and pancreatic cysts, <5% and spleen cysts. Colonic diverticula complication rate can be as high as 80%.

Intracranial aneurysms: incidence of 10% to 40%. The disease aneurysm rupture occurred in middle-aged (average age 39 years), 30% occurred in the usurpation of normal, 46% occurred in patients with normal renal function.

Heart valve abnormalities: mitral valve prolapse, mitral or tricuspid regurgitation.

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